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Protein kinase C intervention: the state of play

Roffey, J. and Rosse, C. and Linch, M. and Hibbert, A. and McDonald, Neil Q. and Parker, P.J. (2009) Protein kinase C intervention: the state of play. Current Opinion in Cell Biology 21 (2), pp. 268-279. ISSN 1879-0410.

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Intervention in protein kinase C (PKC) has a chequered history, partly because of the poor selectivity of many inhibitors and partly a reflection of the sometimes antagonistic action of related PKC isoforms. Recent advances in targeting PKC isoforms have come from structural work on isolated kinase domains that have provided opportunities to drive selectivity through structure-based avenues. The promise of isoform selective inhibitors and the rationale for their development are discussed in the broader context of the PKC inhibitor arsenal.

Item Type: Article
School or Research Centre: Birkbeck Schools and Research Centres > School of Science > Biological Sciences
Depositing User: Administrator
Date Deposited: 04 Aug 2010 14:09
Last Modified: 17 Apr 2013 12:17

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