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    Kinesin-5 mitotic motors: is loop5 the on/off switch?

    Moores, Carolyn A. (2010) Kinesin-5 mitotic motors: is loop5 the on/off switch? Cell Cycle 9 (7), pp. 1286-1290. ISSN 1551-4005.

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    Abstract

    The microtubule-based mitotic spindle orchestrates chromosome segregation, facilitated by many microtubule-associated proteins. Kinesin-5 proteins are important components of the cell division machinery, and are involved in generation of mitotic spindle bipolarity by cross-linking microtubules. Kinesin-5s are members of the ATP- and MT-dependent kinesin superfamily of molecular motors. Human kinesin-5 is also a target for small molecule inhibitors that specifically bind to the motor domain and are currently in cancer clinical trials. The regulatory mechanisms that control kinesin-5 activity during mitosis and the effects of regulation on the kinesin-5-microtubule interaction remain unknown. Recent work has focused on a kinesin-5 specific region within the motor domain, loop5, as a potential regulatory switch. Kinesin-5-specific small molecule inhibitors bind beneath loop5, loop5 is rearranged when kinesin-5 binds to microtubules and residues adjacent to loop5 are subject to cell cycle-dependent tyrosine phosphorylation which could affect its conformation. It will be essential to consider these studies, which shed light on potential kinesin-5 regulatory mechanisms, as part of efforts to develop clinically effective kinesin-5 inhibitors.

    Metadata

    Item Type: Article
    Additional Information: Available via Gold Open Access at official URL
    Keyword(s) / Subject(s): kinesin, microtubule, mitosis, cancer, spindle, KSP, monastrol, Wee1
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Research Centre: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 04 Aug 2010 14:09
    Last Modified: 06 Dec 2016 11:12
    URI: http://eprints.bbk.ac.uk/id/eprint/1043

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