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Structural biology of the p53 tumour suppressor

Okorokov, A.L. and Orlova, Elena V. (2009) Structural biology of the p53 tumour suppressor. Current Opinion in Structural Biology 19 (2), pp. 197-202. ISSN 0959-440X.

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Official URL: http://dx.doi.org/10.1016/j.sbi.2009.02.003

Abstract

The p53 tumour suppressor protein has presented a challenge for structural biology for more than two decades. The complete p53 molecule has eluded numerous attempts to determine its structure, presumably owing to the intrinsic conformational flexibility that is essential to the protein's function. Recent data obtained by X-ray crystallography, NMR spectroscopy and electron microscopy provide new insight into the quaternary architecture of the whole molecule and new strategies for examining how these structures correlate with the cell and molecular biology of the ‘Guardian of the Genome’.

Item Type: Article
School or Research Centre: Birkbeck Schools and Research Centres > School of Science > Biological Sciences
Depositing User: Administrator
Date Deposited: 04 Aug 2010 14:09
Last Modified: 17 Apr 2013 12:17
URI: http://eprints.bbk.ac.uk/id/eprint/1065

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