ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization
Pappalardo, F. and Halling-Brown, Mark D. and Rapin, N. and Zhang, P. and Alemani, D. and Emerson, A. and Paci, P. and Duroux, P. and Pennisi, M. and Palladini, A. and Miotto, O. and Churchill, D. and Rossi, E. and Shepherd, Adrian J. and Moss, David S. and Castiglione, F. and Bernaschi, M. and Lefranc, M.P. and Brunak, S. and Motta, S. and Lollini, P.L. and Basford, K.E. and Brusic, V. (2009) ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization. Briefings in Bioinformatics 10 (3), pp. 330-340. ISSN 1467-5463.
Vaccine research is a combinatorial science requiring computational analysis of vaccine components, formulations and optimization. We have developed a framework that combines computational tools for the study of immune function and vaccine development. This framework, named ImmunoGrid combines conceptual models of the immune system, models of antigen processing and presentation, system-level models of the immune system, Grid computing, and database technology to facilitate discovery, formulation and optimization of vaccines. ImmunoGrid modules share common conceptual models and ontologies. The ImmunoGrid portal offers access to educational simulators where previously defined cases can be displayed, and to research simulators that allow the development of new, or tuning of existing, computational models. The portal is accessible at igrid-ext.cryst.bbk.ac.uk/immunogrid.
|School:||Birkbeck Schools and Departments > School of Science > Biological Sciences|
|Research Centre:||Bioinformatics, Bloomsbury Centre for, Structural Molecular Biology, Institute of (ISMB)|
|Date Deposited:||04 Aug 2010 14:09|
|Last Modified:||07 Dec 2016 15:02|
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