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Understanding the molecular machinery of genetics through 3D structures

Laskowski, R.A. and Thornton, Janet M. (2008) Understanding the molecular machinery of genetics through 3D structures. Nature Reviews Genetics 9 (2), pp. 141-151. ISSN 1471-0064.

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Official URL: http://dx.doi.org/10.1038/nrg2273

Abstract

Detailed knowledge of the three-dimensional structures of biological molecules has had an enormous impact on all areas of biological science, including genetics, as structure can reveal the fine details of how molecules perform their biological functions. Here we consider how changes in protein sequence affect the corresponding 3D structure, and describe how structural information about proteins, DNA and chromatin has shed light on gene regulatory mechanisms and the storage and transmission of epigenetic information. Finally, we describe how structure determination is benefiting from the high-throughput technologies of the worldwide structural genomics projects.

Item Type: Article
School or Research Centre: Birkbeck Schools and Research Centres > School of Science > Biological Sciences
Depositing User: Administrator
Date Deposited: 04 Aug 2010 14:09
Last Modified: 17 Apr 2013 12:17
URI: http://eprints.bbk.ac.uk/id/eprint/1110

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