Missing in action: enzyme functional annotations in biological databases
Furnham, N. and Garavelli, J.S. and Apweiler, R. and Thornton, Janet M. (2009) Missing in action: enzyme functional annotations in biological databases. Nature Chemical Biology 5 , pp. 521-525. ISSN 1552-4469.
Annotations of enzyme function provide critical starting points for generating and testing biological hypotheses, but the quality of functional annotations is hindered by uncertain assignments for uncharacterized sequences and by the relative sparseness of validated experimental data. Given the relentless increase in genomic data, new thinking and validation methods are urgently needed to provide high confidence in enzyme functional assignments.
|School:||Birkbeck Schools and Departments > School of Science > Biological Sciences|
|Date Deposited:||04 Aug 2010 14:09|
|Last Modified:||17 Apr 2013 12:17|
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