Repetitive architecture of the Haemophilus influenzae hia trimeric autotransporter
Waksman, Gabriel and Meng, G.Y. and St. Geme, J.W. (2008) Repetitive architecture of the Haemophilus influenzae hia trimeric autotransporter. Journal of Molecular Biology 384 (4), pp. 824-836. ISSN 0022-2836.
The Hia autotransporter of Haemophilus influenzae belongs to the trimeric autotransporter subfamily and mediates bacterial adherence to the respiratory epithelium. In this report, we show that the structure of Hia is characterized by a modular architecture containing repeats of structurally distinct domains. Comparison of the structures of HiaBD1 and HiaBD2 adhesive repeats and a nonadhesive repeat (a novel fold) shed light on the structural determinants of Hia adhesive function. Examination of the structure of an extended version of the Hia translocator domain revealed the structural transition between the C-terminal translocator domain and the N-terminal passenger domain, highlighting a highly intertwined domain that is ubiquitous among trimeric autotransporters. Overall, this study provides important insights into the mechanism of Hia adhesive activity and the overall structure of trimeric autotransporters.
|Keyword(s) / Subject(s):||Hia, autotransporter, adhesin, structural biology, Haemophilus influenzae|
|School:||Birkbeck Schools and Departments > School of Science > Biological Sciences|
|Research Centre:||Structural Molecular Biology, Institute of (ISMB)|
|Date Deposited:||04 Aug 2010 14:09|
|Last Modified:||06 Dec 2016 10:46|
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