BIROn - Birkbeck Institutional Research Online

    A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

    Wiseman, F. and Fisher, E. and Al_Janabi, T. and Hardy, J. and Karmiloff-Smith, Annette and Nizetic, D. and Tybulewicz, V. and Strydom, A. (2015) A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome. Nature Reviews Neuroscience 16 , pp. 564-574. ISSN 1471-003X.

    12535.pdf - Author's Accepted Manuscript

    Download (696kB) | Preview


    Down syndrome, caused by an extra copy of chromosome 21, is associated with a greatly increased risk of early onset Alzheimer disease. It is thought that this risk is conferred by the presence of three copies of the gene encoding amyloid precursor protein (APP), an Alzheimer risk factor, although the possession of extra copies of other chromosome 21 genes may also play a role. Further study of the mechanisms underlying the development of Alzheimer disease in Down syndrome could provide insights into the mechanisms that cause dementia in the general population.


    Item Type: Article
    Keyword(s) / Subject(s): Down syndrome, Alzheimer's disease, dementia, Amyloid Precursor Protein, trisomy chromosome 21
    School: Birkbeck Schools and Departments > School of Science > Psychological Sciences
    Research Centre: Brain and Cognitive Development, Centre for (CBCD)
    Depositing User: Annette Karmiloff Smith
    Date Deposited: 07 Aug 2015 11:30
    Last Modified: 02 Dec 2016 11:50


    Activity Overview

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item