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    Utilities for high-throughput analysis of B-cell clonal lineages

    Lees, William D. and Shepherd, Adrian J. (2015) Utilities for high-throughput analysis of B-cell clonal lineages. Journal of Immunology Research , p. 323506. ISSN 2314-8861.

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    Abstract

    There are at present few tools available to assist with the determination and analysis of B-cell lineage trees from next-generation sequencing data. Here we present two utilities that support automated large-scale analysis and the creation of publication-quality results. The tools are available on the web, and are also available for download so that they can be integrated into an automated pipeline. Critically, and in contrast to previously published tools, these utilities can be used with any suitable phylogenetic inference method and with any antibody germline library, and hence are species-independent.

    Metadata

    Item Type: Article
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Research Centre: Bioinformatics, Bloomsbury Centre for, Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 03 Aug 2015 11:47
    Last Modified: 07 Dec 2016 15:02
    URI: http://eprints.bbk.ac.uk/id/eprint/12648

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