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    Building an adaptive brain across development: targets for neurorehabilitation must begin in infancy

    Edgin, J. and Clark, C. and Massand, Esha and Karmiloff-Smith, Annette (2015) Building an adaptive brain across development: targets for neurorehabilitation must begin in infancy. Frontiers In Behavioral Neuroscience , ISSN 1662-5153.

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    Abstract

    Much progress has been made toward behavioural and pharmacological intervention in intellectual disability, which was once thought too difficult to treat. Down syndrome research has shown rapid advances, and clinical trials are currently underway, with more on the horizon. Here, we review the literature on the emergent profile of cognitive development in Down syndrome, emphasizing that treatment approaches must consider how some “end state” impairments, such as language deficits, may develop from early alterations in neural systems beginning in infancy. Specifically, we highlight evidence suggesting that there are pre- and early postnatal alterations in brain structure and function in Down syndrome, resulting in disturbed network function across development. We stress that these early alterations are likely amplified by Alzheimer’s disease progression and poor sleep. Focusing on three network hubs (prefrontal cortex, hippocampus, and cerebellum), we discuss how these regions may relate to evolving deficits in cognitive function in individuals with Down syndrome, and to their language profile in particular.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Down Syndrome, Rehabilitation, Treatment, Brain Development, connectivity, Language, Infancy, cerebellum and cognition, Hippocampus, Alzheimer's disease, neuroconstructivism, Executive Function, reading, intervention, cognitive development
    School: Birkbeck Schools and Departments > School of Science > Psychological Sciences
    Research Centre: Brain and Cognitive Development, Centre for (CBCD)
    Depositing User: Dr Esha Massand
    Date Deposited: 24 Aug 2015 08:57
    Last Modified: 02 Dec 2016 11:50
    URI: http://eprints.bbk.ac.uk/id/eprint/12766

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