Shakoor, Sania and Zavos, H. and Haworth, C.M.A. and McGuire, P. and Cardno, A.G. and Freeman, D. and Ronald, Angelica (2016) Association between stressful life events and psychotic experiences in adolescence: evidence for gene-environment correlations. British Journal of Psychiatry 208 (6), pp. 532-538. ISSN 0007-1250.
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Abstract
- Background: Stressful life events (SLEs) are associated with psychotic experiences (PEs). SLEs might act as an environmental risk factor, but may also share a genetic propensity with PEs. - Aims: Estimate the extent to which genetic and environmental factors influence the relationship between SLEs and PEs. - Method: Self and parent-reports from a community-based twin sample (4,830 16-year-old pairs) were analysed using structural equation model-fitting. - Results: SLEs correlated with positive PEs (r = .12-.14, all p<. 001). Modest heritability was shown for PEs (25-57%) and dependent SLEs (32%). Genetic influences explained the majority of the modest covariation between dependent SLEs and paranoia and cognitive disorganisation (bivariate heritabilities = 74-86%). The relationship between SLEs and hallucinations and grandiosity was explained by both genetic and common environmental effects. - Conclusion: Further to dependent SLEs being an environmental risk factor, individuals may have an underlying genetic propensity increasing their risk of dependent SLEs and positive PEs.
Metadata
| Item Type: | Article |
|---|---|
| Additional Information: | This is an author-produced electronic version of an article accepted for publication in the British Journal of Psychiatry. The definitive publisher-authenticated version is available online at the link above. |
| School: | Birkbeck Faculties and Schools > Faculty of Science > School of Psychological Sciences |
| Research Centres and Institutes: | Brain and Cognitive Development, Centre for (CBCD) |
| Depositing User: | Angelica Ronald |
| Date Deposited: | 18 Apr 2016 14:54 |
| Last Modified: | 02 Aug 2023 17:18 |
| URI: | https://eprints.bbk.ac.uk/id/eprint/13081 |
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