Association between stressful life events and psychotic experiences in adolescence: evidence for gene-environment correlations
Shakoor, Sania and Zavos, H. and Haworth, C.M.A. and McGuire, P. and Cardno, A.G. and Freeman, D. and Ronald, Angelica (2016) Association between stressful life events and psychotic experiences in adolescence: evidence for gene-environment correlations. British Journal of Psychiatry , ISSN 0007-1250.
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- Background: Stressful life events (SLEs) are associated with psychotic experiences (PEs). SLEs might act as an environmental risk factor, but may also share a genetic propensity with PEs. - Aims: Estimate the extent to which genetic and environmental factors influence the relationship between SLEs and PEs. - Method: Self and parent-reports from a community-based twin sample (4,830 16-year-old pairs) were analysed using structural equation model-fitting. - Results: SLEs correlated with positive PEs (r = .12-.14, all p<. 001). Modest heritability was shown for PEs (25-57%) and dependent SLEs (32%). Genetic influences explained the majority of the modest covariation between dependent SLEs and paranoia and cognitive disorganisation (bivariate heritabilities = 74-86%). The relationship between SLEs and hallucinations and grandiosity was explained by both genetic and common environmental effects. - Conclusion: Further to dependent SLEs being an environmental risk factor, individuals may have an underlying genetic propensity increasing their risk of dependent SLEs and positive PEs.
|Additional Information:||This is an author-produced electronic version of an article accepted for publication in the British Journal of Psychiatry. The definitive publisher-authenticated version is available online at the link above.|
|School:||Birkbeck Schools and Departments > School of Science > Psychological Sciences|
|Research Centre:||Brain and Cognitive Development, Centre for (CBCD)|
|Depositing User:||Angelica Ronald|
|Date Deposited:||18 Apr 2016 14:54|
|Last Modified:||02 Dec 2016 11:55|
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