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    Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

    Robinson, E.B. and St Pourcain, B. and Anttila, V. and Kosmicki, J. and Bulik-­‐Sullivan, B. and Grove, J. and Maller, J. and Samocha, K.E. and Sanders, S. and Ripke, S. and Martin, J. and Hollegaard, M.V. and Werge, T. and Hougaard, D.M. and iPSYCH-­‐SSI-­‐Broad Autism Group, A. and Neale, B.M. and Evans, D.M. and Skuse, D. and Mortensen, P.B. and Børglum, A.D. and Ronald, Angelica and Davey Smith, G. and Daly, M.J. (2016) Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population. Nature Genetics 48 (5), pp. 552-555. ISSN 1061-4036.

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    Abstract

    Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the general population, but the effects of that risk are unclear in people not ascertained for neuropsychiatric symptoms. Using several large ASD consortia and population based resources, we find genetic links between ASDs and typical variation in social behavior and adaptive functioning. This finding is evidenced through both inherited and de novo variation, indicating that multiple types of genetic risk for ASDs influence a continuum of behavioral and developmental traits, the severe tail of which can result in an ASD or other neuropsychiatric disorder diagnosis. A continuum model should inform the design and interpretation of studies of neuropsychiatric disease biology.

    Metadata

    Item Type: Article
    School: Birkbeck Schools and Departments > School of Science > Psychological Sciences
    Research Centre: Brain and Cognitive Development, Centre for (CBCD)
    Depositing User: Angelica Ronald
    Date Deposited: 18 Apr 2016 15:29
    Last Modified: 02 Dec 2016 11:55
    URI: http://eprints.bbk.ac.uk/id/eprint/14317

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