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    The nitric oxide synthesis inhibitor L-NAME produces anxiogenic-like effects in the rat elevated plus-maze test, but not in the social interaction test

    Vale, A.L. and Green, Simon and Montgomery, A.M.J. and Shafi, S. (1998) The nitric oxide synthesis inhibitor L-NAME produces anxiogenic-like effects in the rat elevated plus-maze test, but not in the social interaction test. Journal of Psychopharmacology 12 (3), pp. 268-272. ISSN 0269-8811.

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    Abstract

    The effects of the nitric oxide synthase inhibitor, Nw-nitro-L-arginine methyl ester (L-NAME) were investigated in two animal models of anxiety: the elevated plus-maze and the social interaction test. In the elevated plus- maze, L-NAME (12.5-50 mg/kg) had an anxiogenic-like profile as indicated by dose-dependent reductions in the time spent on the open arms, open arm entries, the percentage of open arm entries and head dips, but there was no significant effect on the number of stretch attend postures. In contrast, L-NAME (12.5-50 mg/kg) failed to modify time spent in social interaction but did reduce a measure of vertical activity The differential effects of L-NAME in the two anxiety paradigms are discussed.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): anxiogenic, elevated plus-maze, Nw-nitro-L-arginine methyl ester (L-NAME), nitric oxide rats, social interaction
    School: Birkbeck Schools and Departments > School of Science > Psychological Sciences
    Depositing User: Administrator
    Date Deposited: 16 Feb 2016 10:29
    Last Modified: 16 Feb 2016 10:29
    URI: http://eprints.bbk.ac.uk/id/eprint/14329

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