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    The importance of understanding individual differences in Down syndrome

    Karmiloff Smith, Annette and Al-Janabi, T. and D'Souza, Hana and Groet, J. and Massand, Esha and Mok, K. and Startin, C. and Fisher, E. and Hardy, J. and Nizetic, D. and Tybulewicz, V. and Strydom, A. (2016) The importance of understanding individual differences in Down syndrome. F1000Research 5 , p. 389. ISSN 2046-1402.

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    Abstract

    In this article, we first present a summary of the general assumptions about Down syndrome (DS) still to be found in the literature. We go on to show how new research has modified these assumptions, pointing to a wide range of individual differences at every level of description. We argue that, in the context of significant increases in DS life expectancy, a focus on individual differences in trisomy 21 at all levels—genetic, cellular, neural, cognitive, behavioral, and environmental—constitutes one of the best approaches for understanding genotype/phenotype relations in DS and for exploring risk and protective factors for Alzheimer’s disease in this high-risk population.

    Metadata

    Item Type: Article
    School: Birkbeck Schools and Departments > School of Science > Psychological Sciences
    Research Centre: Brain and Cognitive Development, Centre for (CBCD)
    Depositing User: Administrator
    Date Deposited: 14 Apr 2016 08:37
    Last Modified: 02 Dec 2016 11:17
    URI: http://eprints.bbk.ac.uk/id/eprint/14938

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