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    One face of Chlamydia trachomatis: the infectious elementary body

    Cossé, M.M. and Hayward, Richard D. and Subtil, A. (2016) One face of Chlamydia trachomatis: the infectious elementary body. In: UNSPECIFIED (ed.) Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology 412. Berlin, Germany: Springer, pp. 35-58. ISBN 9783319712307.

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    Abstract

    The lifestyle of Chlamydiae is unique: the bacteria alternate between two morphologically distinct forms, an infectious non-replicative elementary body (EB), and a replicative, non-infectious reticulate body (RB). This review focuses on recent advances in understanding the structure and function of the infectious form of the best-studied member of the phylum, the human pathogen Chlamydia trachomatis. Once considered as an inert particle of little functional capacity, the EB is now perceived as a sophisticated entity that encounters at least three different environments during each infectious cycle. We review current knowledge on its composition and morphology, and emerging metabolic activities. These features confer resistance to the extracellular environment, the ability to penetrate a host cell and ultimately enable the EB to establish a niche enabling bacterial survival and growth. The bacterial and host molecules involved in these processes are beginning to emerge.

    Metadata

    Item Type: Book Section
    Additional Information: Series ISSN: 0070-217X
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Research Centre: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 03 Jun 2016 15:55
    Last Modified: 01 Aug 2018 11:37
    URI: http://eprints.bbk.ac.uk/id/eprint/15421

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