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    Genetic and environmental components of female depression as a function of the severity of the disorder

    Rusby, J.S.M. and Tasker, Fiona and Cherkas, L. (2016) Genetic and environmental components of female depression as a function of the severity of the disorder. Brain & Behavior 6 (10), e00519. ISSN 2162-3279.

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    Abstract

    Background: Both clinical care and genome-wide studies need to account for levels of severity in the etiology of depression. The purpose of the study is to estimate the genetic and environmental components of female depression as a function of the severity of the disorder. Methods: A genetic and environmental model analysis of depression incidence was made using the IOP Depression Severity Measure (IDSM). Details of lifetime depression incidence was obtained by questionnaire from twins on the DTR registry. Data from 1449 matched female twin pairs in the age range 19-85 years in four ordinal categories of increasing severity were employed in the analysis. Results: Estimates of additive and dominance genetic components of 27% and 25% were found when all three levels of depression were included, and near zero and 33% when the recurrent/severe level was excluded. Shared environmental effects were not significant in either case but the estimate for random environmental effects was greater when the severe level was excluded. Conclusions: These results suggest that the incidence of severe depression is associated with homozygotic alleles and the less severe with heterozygotic alleles. This is in accord with the finding that the hereditary component of severe depression is relatively high and that milder forms are more dependent on life-time environmental factors. Such conclusions have clinical implications for the diagnosis and treatment of the disorder by practicing psychiatrists. They also lead to the importance of focusing future genome-wide and linkage studies on those females with severe levels of depression if progress in identifying genetic risk loci is to be made.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Twin studies, major depression, additive and dominance estimates, heritability, mood disorders, homozygotic and heterozygotic alleles
    School: Birkbeck Schools and Departments > School of Science > Psychological Sciences
    Research Centre: Children, Families and Social Issues, Institute for the Study of
    Depositing User: Fiona Tasker
    Date Deposited: 26 Aug 2016 08:12
    Last Modified: 09 Feb 2017 15:44
    URI: http://eprints.bbk.ac.uk/id/eprint/15495

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