BIROn - Birkbeck Institutional Research Online

    UV-curable gels as topical nail medicines: in vivo residence, anti-fungal efficacy and influence of gel components on their properties

    Kerai, L.V. and Hilton, S. and Maugueret Minerve, Tafie and Kazi, Bilkis Banu and Nicklin, Jane and Bhakta, Sanjib and Murdan, S. (2016) UV-curable gels as topical nail medicines: in vivo residence, anti-fungal efficacy and influence of gel components on their properties. International Journal of Pharmaceutics 514 (1), pp. 244-254. ISSN 0378-5173.

    [img]
    Preview
    Text
    16056.pdf - Author's Accepted Manuscript
    Available under License Creative Commons Attribution Non-commercial No Derivatives.

    Download (2MB) | Preview

    Abstract

    UV-curable gels, used as nail cosmetics for their in vivo durability, were reported to be promising as topical nail medicines. Our first aim was thus to investigate whether such durability applies to drug-loaded formulations. This was found to be true. However, ethanol inclusion in the pharmaceutical formulation (to enable drug loading) reduced the in vivo residence. The second aim was therefore to determine any other effects of ethanol, and if ethanol could be avoided by the choice of monomers. Thus, three methacrylate monomers, ethyl methacrylate, isobornyl methacrylate and 2-hydroxyethyl methacrylate (HEMA) were selected, and their influence on the formulation properties were determined. Ethanol and the methacrylate monomer influenced some (but not all) of the formulation properties. The most significant was that HEMA could dissolve drug and enable the preparation of ethanol-free, drug-loaded formulations, which would benefit in vivo residence. The absence of ethanol reduced drug loading, release and ungual flux, but had no negative impact on the in vitro anti-fungal efficacy. Thus, judicious selection of gel components enabled the exclusion of ethanol. The long in vivo residence, little residual monomers, sufficient ungual permeation and in vitro anti-fungal activity of the gels indicates their potential as anti-onychomycotic topical medicines.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): UV gel, acrylate, Ungual, Release, Permeation, Anti-fungal efficacy, In vivo, Residence, Onychomycosis, amorolfine, terbinafine, TOWL
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Research Centre: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 15 Sep 2016 14:57
    Last Modified: 16 Nov 2017 01:10
    URI: http://eprints.bbk.ac.uk/id/eprint/16056

    Statistics

    Downloads
    Activity Overview
    50Downloads
    78Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item