BIROn - Birkbeck Institutional Research Online

    Mid-childhood outcomes of infant siblings at familial high-risk of Autism Spectrum Disorder

    Shephard, E. and Milosavljevic, B. and Pasco, G. and Jones, Emily and Gliga, Teodora and Happe, F. and Johnson, Mark H. and Charman, T. (2017) Mid-childhood outcomes of infant siblings at familial high-risk of Autism Spectrum Disorder. Autism Research 10 (3), pp. 546-557. ISSN 1939-3792.

    [img]
    Preview
    Text
    17791.pdf - Published Version of Record
    Available under License Creative Commons Attribution.

    Download (146kB) | Preview

    Abstract

    Almost one-in-five infants at high familial risk for autism spectrum disorder (ASD), due to having an older sibling with an ASD diagnosis, develop ASD themselves by age 3 years. Less is known about the longer-term outcomes of high-risk infants. To address this issue, we examined symptoms of ASD and associated developmental conditions (attention-deficit/hyperactivity disorder (ADHD); anxiety), language, IQ, and adaptive behaviour at age 7 years in high- and low-risk children studied from infancy. We compared outcomes between high-risk children who met criteria for ASD at age 7, high-risk children without ASD, and low-risk control children. Diagnostic stability between 3 and 7 years was moderate. High-risk siblings with ASD showed elevated levels of ADHD and anxiety symptoms and lower adaptive behaviour than low-risk control children. High-risk siblings without ASD had higher repetitive behaviours, lower adaptive functioning, and elevated scores on one anxiety subscale (Separation Anxiety) compared to low-risk controls. The findings indicate that the difficulties experienced by high-risk siblings at school age extend beyond ASD symptoms. Better understanding of these difficulties may improve models of the development of co-occurring problems seen in children with ASD. Autism Res 2016.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): high-risk siblings, clinical outcomes, ADHD, anxiety, broader autism phenotype
    School: Birkbeck Schools and Departments > School of Science > Psychological Sciences
    Research Centre: Brain and Cognitive Development, Centre for (CBCD)
    Depositing User: Emily Jones
    Date Deposited: 17 Jan 2017 15:09
    Last Modified: 09 May 2017 13:49
    URI: http://eprints.bbk.ac.uk/id/eprint/17791

    Statistics

    Downloads
    Activity Overview
    24Downloads
    68Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item