Mid-childhood outcomes of infant siblings at familial high-risk of Autism Spectrum Disorder
Shephard, E. and Milosavljevic, B. and Pasco, G. and Jones, Emily and Gliga, Teodora and Happe, F. and Johnson, Mark and Charman, T. (2016) Mid-childhood outcomes of infant siblings at familial high-risk of Autism Spectrum Disorder. Autism Research , ISSN 1939-3792. (In Press)
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Almost one-in-five infants at high familial risk for autism spectrum disorder (ASD), due to having an older sibling with an ASD diagnosis, develop ASD themselves by age 3 years. Less is known about the longer-term outcomes of high-risk infants. To address this issue, we examined symptoms of ASD and associated developmental conditions (attention-deficit/hyperactivity disorder (ADHD); anxiety), language, IQ, and adaptive behaviour at age 7 years in high- and low-risk children studied from infancy. We compared outcomes between high-risk children who met criteria for ASD at age 7, high-risk children without ASD, and low-risk control children. Diagnostic stability between 3 and 7 years was moderate. High-risk siblings with ASD showed elevated levels of ADHD and anxiety symptoms and lower adaptive behaviour than low-risk control children. High-risk siblings without ASD had higher repetitive behaviours, lower adaptive functioning, and elevated scores on one anxiety subscale (Separation Anxiety) compared to low-risk controls. The findings indicate that the difficulties experienced by high-risk siblings at school age extend beyond ASD symptoms. Better understanding of these difficulties may improve models of the development of co-occurring problems seen in children with ASD. Autism Res 2016.
|Keyword(s) / Subject(s):||high-risk siblings, clinical outcomes, ADHD, anxiety, broader autism phenotype|
|School:||Birkbeck Schools and Departments > School of Science > Psychological Sciences|
|Research Centre:||Brain and Cognitive Development, Centre for (CBCD)|
|Depositing User:||Emily Jones|
|Date Deposited:||17 Jan 2017 15:09|
|Last Modified:||17 Jan 2017 15:09|
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