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Effect of conjugates of all-trans-retinoic acid and shorter polyene chain analogues with amino acids on prostate cancer cell growth

Sadikoglou, E. and Magoulas, George D. and Theodoropoulou, C. and Athanassopoulos, C.M. and Giannopoulou, E. and Theodorakopoulou, O. and Drainas, D. and Papaioannou, D. and Papadimitriou, E. (2009) Effect of conjugates of all-trans-retinoic acid and shorter polyene chain analogues with amino acids on prostate cancer cell growth. European Journal of Medicinal Chemistry 44 (8), pp. 3175-3187. ISSN 0223-5234.

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Official URL: http://dx.doi.org/10.1016/j.ejmech.2009.03.029

Abstract

In the present work, a series of conjugates of amino acids with all-trans-retinoic acid (ATRA) and shorter polyene chain analogues were rationally designed, synthesized by coupling the succinimidyl active esters of the acidic retinoids with appropriately protected amino acids or peptides followed by deprotection, and examined for their possible effect on viability of human prostate cancer LNCaP cells. In contrast to ATRA, all conjugates bearing amino acids with polar side chains showed no inhibitory effect on LNCaP cell proliferation, while conjugates with α-amino acids with lipophilic side chain, such as 7, or linear amino acids, such as 9, significantly decreased prostate cancer LNCaP cell number. Interestingly, while the effect of ATRA was RARα-dependent, the effect of its active analogues was not inhibited by a selective RARα antagonist. Cell cycle analysis showed no effect on cell cycle, while quantitative analysis by annexin V-propidium iodide staining revealed that neither ATRA nor its analogues affected LNCaP cell apoptosis or necrosis. These results demonstrate that compounds 7 and 9 are potentially useful agents that warrant further preclinical development for treatment of prostate cancer.

Item Type: Article
Keyword(s) / Subject(s): Retinoid, amino acid, conjugate, prostate cancer cells, retinoid receptors
School or Research Centre: Birkbeck Schools and Research Centres > School of Business, Economics & Informatics > Computer Science and Information Systems
Depositing User: Administrator
Date Deposited: 04 Feb 2011 15:53
Last Modified: 17 Apr 2013 12:18
URI: http://eprints.bbk.ac.uk/id/eprint/1874

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