Preparation of spermine conjugates with acidic retinoids with potent ribonuclease P inhibitory activity
Magoulas, George D. and Papaioannou, D. and Papadimou, E. and Drainas, D. (2009) Preparation of spermine conjugates with acidic retinoids with potent ribonuclease P inhibitory activity. European Journal of Medicinal Chemistry 44 (6), pp. 2689-2695. ISSN 0223-5234.
Novel mono- and diacylated spermines, readily obtained using isolable succinimidyl active esters of acidic retinoids for the selective acylation of free spermine or in situ activated acidic retinoids for acylating selectively protected spermine followed by deprotection, were shown to inhibit the ribozyme ribonuclease P more strongly than the parent retinoids.
|Keyword(s) / Subject(s):||ATRA, all-trans-retinoic acid, ACI, acitretin, Ch, cyclohexyl, DCM, dichloromethane, SPM, spermine, RAR, retinoic acid receptor, RXR, retinoid X receptor, RNase P, ribonuclease P, RT, room temperature, TFA, trifluoroacetic acid|
|School:||Birkbeck Schools and Departments > School of Business, Economics & Informatics > Computer Science and Information Systems|
|Research Centre:||Birkbeck Knowledge Lab|
|Date Deposited:||04 Feb 2011 15:37|
|Last Modified:||02 Dec 2016 13:23|
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