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Preparation of spermine conjugates with acidic retinoids with potent ribonuclease P inhibitory activity

Magoulas, George D. and Papaioannou, D. and Papadimou, E. and Drainas, D. (2009) Preparation of spermine conjugates with acidic retinoids with potent ribonuclease P inhibitory activity. European Journal of Medicinal Chemistry 44 (6), pp. 2689-2695. ISSN 0223-5234.

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Official URL: http://dx.doi.org/10.1016/j.ejmech.2009.01.001

Abstract

Novel mono- and diacylated spermines, readily obtained using isolable succinimidyl active esters of acidic retinoids for the selective acylation of free spermine or in situ activated acidic retinoids for acylating selectively protected spermine followed by deprotection, were shown to inhibit the ribozyme ribonuclease P more strongly than the parent retinoids.

Item Type: Article
Keyword(s) / Subject(s): ATRA, all-trans-retinoic acid, ACI, acitretin, Ch, cyclohexyl, DCM, dichloromethane, SPM, spermine, RAR, retinoic acid receptor, RXR, retinoid X receptor, RNase P, ribonuclease P, RT, room temperature, TFA, trifluoroacetic acid
School or Research Centre: Birkbeck Schools and Research Centres > School of Business, Economics & Informatics > Computer Science and Information Systems
Depositing User: Administrator
Date Deposited: 04 Feb 2011 15:37
Last Modified: 17 Apr 2013 12:18
URI: http://eprints.bbk.ac.uk/id/eprint/1879

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