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    Interpreting the functional role of a novel interaction motif in prokaryotic sodium channels

    Sula, Altin and Wallace, Bonnie A. (2017) Interpreting the functional role of a novel interaction motif in prokaryotic sodium channels. The Journal of General Physiology 149 (6), pp. 613-622. ISSN 0022-1295.

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    Abstract

    Voltage-gated sodium channels enable the translocation of sodium ions across cell membranes and play crucial roles in electrical signaling by initiating the action potential. In humans, mutations in sodium channels give rise to several neurological and cardiovascular diseases, and hence they are targets for pharmaceutical drug developments. Prokaryotic sodium channel crystal structures have provided detailed views of sodium channels, which by homology have suggested potentially important functionally related structural features in human sodium channels. A new crystal structure of a full-length prokaryotic channel, NavMs, in a conformation we proposed to represent the open, activated state, has revealed a novel interaction motif associated with channel opening. This motif is associated with disease when mutated in human sodium channels and plays an important and dynamic role in our new model for channel activation.

    Metadata

    Item Type: Article
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Depositing User: Administrator
    Date Deposited: 14 Jun 2017 09:17
    Last Modified: 04 Sep 2017 14:20
    URI: http://eprints.bbk.ac.uk/id/eprint/18919

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