BIROn - Birkbeck Institutional Research Online

    Structural and molecular biology of a protein-polymerizing nanomachine for pilus biogenesis

    Waksman, Gabriel (2017) Structural and molecular biology of a protein-polymerizing nanomachine for pilus biogenesis. Journal of Molecular Biology 429 (17), pp. 2654-2666. ISSN 0022-2836.

    [img]
    Preview
    Text
    19232.pdf - Published Version of Record
    Available under License Creative Commons Attribution Non-commercial No Derivatives.

    Download (1MB) | Preview

    Abstract

    Bacteria produce protein polymers on their surface called pili or fimbriae that serve either as attachment devices or as conduits for secreted substrates. This review will focus on the chaperone–usher pathway of pilus biogenesis, a widespread assembly line for pilus production at the surface of Gram-negative bacteria and the archetypical protein-polymerizing nanomachine. Comparison with other nanomachines polymerizing other types of biological units, such as nucleotides during DNA replication, provides some unifying principles as to how multidomain proteins assemble biological polymers.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Pilus biogenesis, Usher, Chaperone, DNA polymerase I, Nanomachine
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Depositing User: Administrator
    Date Deposited: 21 Jul 2017 12:34
    Last Modified: 04 Jun 2018 14:18
    URI: http://eprints.bbk.ac.uk/id/eprint/19232

    Statistics

    Downloads
    Activity Overview
    40Downloads
    53Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item