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    Myostatin-like proteins regulate synaptic function and neuronal morphology

    Augustin, H. and McGourty, K. and Steinert, J.R. and Cochemé, H.M. and Adcott, J. and Cabecinha, M. and Vincent, A. and Halff, E.F. and Kittler, J.T. and Boucrot, Emmanuel and Partridge, L. (2017) Myostatin-like proteins regulate synaptic function and neuronal morphology. Development 144 (13), pp. 2445-2455. ISSN 0950-1991.

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    Abstract

    Growth factors of the TGFβ superfamily play key roles in regulating neuronal and muscle function. Myostatin (or GDF8) and GDF11 are potent negative regulators of skeletal muscle mass. However, expression of myostatin and its cognate receptors in other tissues, including brain and peripheral nerves, suggests a potential wider biological role. Here, we show that Myoglianin (MYO), the Drosophila homolog of myostatin and GDF11, regulates not only body weight and muscle size, but also inhibits neuromuscular synapse strength and composition in a Smad2-dependent manner. Both myostatin and GDF11 affected synapse formation in isolated rat cortical neuron cultures, suggesting an effect on synaptogenesis beyond neuromuscular junctions. We also show that MYO acts in vivo to inhibit synaptic transmission between neurons in the escape response neural circuit of adult flies. Thus, these anti-myogenic proteins act as important inhibitors of synapse function and neuronal growth.

    Metadata

    Item Type: Article
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Depositing User: Administrator
    Date Deposited: 14 Aug 2017 14:23
    Last Modified: 14 Aug 2017 14:23
    URI: http://eprints.bbk.ac.uk/id/eprint/19387

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