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    Enhanced pupillary light reflex in infancy is associated with autism diagnosis in toddlerhood

    Nyström, P. and Gliga, Teodora and Nilsson Jobs, E. and Gredebäck, G. and Charman, T. and Johnson, Mark H. and Bölte, S. and Falck-Ytter, T. (2018) Enhanced pupillary light reflex in infancy is associated with autism diagnosis in toddlerhood. Nature Communications 9 (1), p. 1678. ISSN 2041-1723.

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    Abstract

    Autism spectrum disorder (ASD) is a neurodevelopmental condition affecting around 1% of the population. We previously discovered that infant siblings of children with ASD had stronger pupillary light reflexes compared to low-risk infants, a result which contrasts sharply with the weak pupillary light reflex typically seen in both children and adults with ASD. Here, we show that on average the relative constriction of the pupillary light reflex is larger in 9-10-month-old high risk infant siblings who receive an ASD diagnosis at 36 months, compared both to those who do not and to low-risk controls. We also found that the magnitude of the pupillary light reflex in infancy is associated with symptom severity at follow-up. This study indicates an important role of sensory atypicalities in the etiology of ASD, and suggests that pupillometry, if further developed and refined, could facilitate risk assessment in infants.

    Metadata

    Item Type: Article
    School: Birkbeck Schools and Departments > School of Science > Psychological Sciences
    SWORD Depositor: Mr Joe Tenant
    Depositing User: Mr Joe Tenant
    Date Deposited: 22 May 2018 13:40
    Last Modified: 22 May 2018 13:40
    URI: http://eprints.bbk.ac.uk/id/eprint/22461

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