Banerjee, I. and Shevlin, M. and Taranissi, M. and Thornhill, A. and Abdalla, H. and Ozturk, O. and Barnes, Jacqueline and Sutcliffe, A. (2008) Health of children conceived after preimplantation genetic diagnosis: a preliminary outcome study. Reproductive BioMedicine Online 16 (3), pp. 376-381. ISSN 1472-6483.Full text not available from this repository.
A preliminary study was conducted on health of children conceived after preimplantation genetic screening and diagnosis (PGD). Forty-nine children were assessed with 66 matched naturally conceived (NC) controls. Primary outcome was neurodevelopmental screening, and secondary outcomes were evidence of other health problems and assessment of parent-child relationships. Study and control children were well matched across relevant socio-demographic variables. Growth parameters at mean age 18 months were normal. The mean Griffiths quotient was 102.7 (+/-13.1) (PGD) and 103.3 (+/-12.8) (NC), both of which were within the normal range, and did not differ significantly. PGD cases were more likely to be lighter, at <2500 g (12 children, 24.5% versus one child 1.5%, P < 0.0001) and born earlier than controls (38.2 +/- 2.6 versus 40.0 +/- 1.4 weeks; P < 0.0001), consistent with other similar studies. PGD families showed no evidence of excess stress in their relationship with their child. The PGD group had significantly higher scores on the warmth-affection sub-scale (P = 0.042), and significantly lower scores on the aggression-hostility and rejection sub-scales (P = 0.030) of the questionnaire. The study showed no major ill effects from PGD on the child health. A larger study is needed to confirm the validity of this conclusion.
|Keyword(s) / Subject(s):||children, health, neurodevelopmental, outcome, preimplantation genetic diagnosis, preimplantation genetic screening|
|School or Research Centre:||Birkbeck Schools and Research Centres > School of Science > Psychological Sciences|
|Date Deposited:||07 Jan 2011 15:50|
|Last Modified:||17 Apr 2013 12:18|
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