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Amygdala damage affects event-related potentials for fearful faces at specific time windows

Rotshtein, P. and Richardson, M.P. and Winston, J.S. and Kiebel, S.J. and Vuilleumier, P. and Eimer, Martin and Driver, J. and Dolan, R.J. (2010) Amygdala damage affects event-related potentials for fearful faces at specific time windows. Human Brain Mapping 31 (7), pp. 1089-1105. ISSN 1065-9471.

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Official URL: http://dx.doi.org/10.1002/hbm.20921

Abstract

The amygdala is known to influence processing of threat-related stimuli in distant brain regions, including visual cortex. The time-course of these distant influences is unknown, although this information is important for resolving debates over likely pathways mediating an apparent rapidity in emotional processing. To address this, we recorded event-related potentials (ERPs) to seen fearful face expressions, in preoperative patients with medial temporal lobe epilepsy who had varying degrees of amygdala pathology, plus healthy volunteers. We found that amygdala damage diminished ERPs for fearful versus neutral faces within the P1 time-range, 100-150 ms, and for a later component at 500-600 ms. Individual severity of amygdala damage determined the magnitude of both these effects, consistent with a causal amygdala role. By contrast, amygdala damage did not affect explicit perception of fearful expressions nor a distinct emotional ERP effect at 150-250 ms. These results demonstrate two distinct time-points at which the amygdala influences fear processing. The data also demonstrate that while not all aspects of expression processing are disrupted by amygdala damage, there is a crucial impact on an early P1 component. These findings are consistent with the existence of multiple processing stages or routes for fearful faces that vary in their dependence on amygdala function. Hum Brain Mapp, 2010.

Item Type: Article
Keyword(s) / Subject(s): ERP, medial temporal lobe epilepsy, emotion, P1, late-P3, SPM5
School or Research Centre: Birkbeck Schools and Research Centres > School of Science > Psychological Sciences
Depositing User: Administrator
Date Deposited: 05 Jan 2011 12:04
Last Modified: 17 Apr 2013 12:19
URI: http://eprints.bbk.ac.uk/id/eprint/2389

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