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Induced hyperlipaemia and immune challenge in locusts

Mullen, Lisa M. and Lightfoot, M.E. and Goldsworthy, Graham J. (2004) Induced hyperlipaemia and immune challenge in locusts. Journal of Insect Physiology 50 (5), pp. 409-417. ISSN 0022-1910.


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Injections of immunogens, such as β-1,3-glucan or lipopolysaccharide (LPS), bring about a marked hyperlipaemia with associated changes in lipophorins and apolipophorin-III in the haemolymph of Locusta migratoria. These changes are similar to those observed after injection of adipokinetic hormone (AKH). The possibility that endogenous AKH is released as part of the response to these immunogens is investigated using passive immunisation against AKH-I, and measurement of AKH-I titre in the haemolymph after injection of immunogens. The data presented show that, despite the similarity of the changes brought about by the presence of immunogens in the haemolymph to those brought about by AKH, there is no release of endogenous AKH after injection of laminarin or LPS. A direct effect of the immunogens on release of neutral lipids by the fat body cannot be demonstrated in vitro, and the mechanism by which hyperlipaemia is induced during immune challenge remains uncertain.

Item Type: Article
Additional Information: *No ID available (PR 18.8.11)
Keyword(s) / Subject(s): AKH, Locusta, Immunogens, LPS, Laminarin, ELISA, Phenoloxidase, LDLp, ApoLp-III, Fat body, Passive immunisation; β-1,3-glucan, enzyme-linked immunosorbent assay, lipopolysaccharide, adipokinetic hormone, apolipophorin-III
School or Research Centre: Birkbeck Schools and Research Centres > School of Science > Biological Sciences
Depositing User: Administrator
Date Deposited: 05 Oct 2005
Last Modified: 17 Apr 2013 12:32

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