Goldsworthy, Graham J. and Opoku-Ware, K. and Mullen, Lisa M. (2002) Adipokinetic hormone enhances laminarin and bacterial lipopolysaccharide-induced activation of the prophenoloxidase cascade in the African migratory locust, Locusta migratoria. Journal of Insect Physiology 48 (6), pp. 601-608. ISSN 0022-1910.
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Lom-AKH-I enhances the activation in vivo of prophenoloxidase in the haemolymph of the African migratory locust, Locusta migratoria, in response to challenge with laminarin. AKH does not influence the speed or initial magnitude of the phenoloxidase response to laminarin, but prolongs the period of activation of the enzyme in a dose-dependent manner. Injections of preparations of bacterial lipopolysaccharide (LPS) do not activate prophenoloxidase in vivo, but co-injection of Lom-AKH-I with commercial preparations of LPS from Klebsiella pneumoniae, Escherichia coli, or Shigella flexneri (but not one from Pseudomonas aeroginosa) results in dose-dependent increases in the levels of phenoloxidase that persist in the haemolymph for several hours. It is argued that the effects of AKH on phenoloxidase activation in locusts described here are, at least in part, related directly to changes in lipid metabolism brought about by the hormone.
|Additional Information:||*No ID available (PR 18.8.11)|
|Keyword(s) / Subject(s):||In vivo, Adipokinetic hormone, Immune response, Phenoloxidase, Lipopolysaccharide, Laminarin, Locusta migratoria|
|School or Research Centre:||Birkbeck Schools and Research Centres > School of Science > Biological Sciences|
|Date Deposited:||26 Oct 2005|
|Last Modified:||17 Apr 2013 12:32|
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