Lim, Chang-Kee and Lord, Gwyn A. (2002) Current developments in LC-MS for pharmaceutical analysis. Biological and Pharmaceutical Bulletin 25 (5), pp. 547-557. ISSN 0918-6158.
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The current developments in liquid chromatography-mass spectrometry (LC-MS) and its applications to the analysis of pharmaceuticals are reviewed. Various mass spectrometric techniques, including electrospray and nanospray ionization, atmospheric pressure chemical ionization and photoionization and their interface with liquid chromatographic techniques are described. These include high performance liquid chromatography, capillary electrophoresis and capillary electrochromatography and the advantages and disadvantages of each technique are discussed. The applications of LC-MS to the studies of in vitro and in vivo drug metabolism, identification and characterization of impurities in pharmaceuticals, analysis of chiral impurities in drug substances and high-throughput LC-MS-MS systems for applications in the “accelerated drug discovery” process are described.
|Keyword(s) / Subject(s):||liquid chromatography-mass spectrometry, pharmaceutical analysis, drug metabolism study, drug discovery, impurities identification, high-throughput LC-MS-MS|
|School or Research Centre:||Birkbeck Schools and Research Centres > School of Science > Biological Sciences|
|Date Deposited:||31 Oct 2005|
|Last Modified:||17 Apr 2013 12:32|
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