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    Staged decline of visual processing capacity in mild cognitive impairment and Alzheimer's disease

    Muller, Hermann J. and Bublak, P. and Redel, P. and Sorg, C. and Kurz, A. and Förstl, H. and Schneider, W.X. and Finke, K. (2011) Staged decline of visual processing capacity in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging 32 (7), pp. 1219-1230. ISSN 0197-4580.

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    Abstract

    Visual information intake was assessed with a whole-report task in patients with probable Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy elderly control subjects. Based on a theory of visual attention (TVA), four parameters were derived characterising different aspects of visual processing capacity: perceptual threshold, iconic memory, processing speed, and visual short-term memory (VSTM) storage capacity. Results indicated increased perceptual thresholds in MCI, and an additional decline in processing speed and VSTM storage capacity in AD. Cholinomimetic medication had beneficial effects on processing speed in AD patients. Perceptual thresholds were associated with disease duration, but not with cognitive measures, while the reverse was true for speed and VSTM measures. These results reveal a staged pattern of deficits affecting pre-attentive visual processing in MCI, and attentive processing in AD. It is compatible with the amyloid cascade hypothesis and suggests that impaired visual processing is a pathological feature present already at the MCI stage and might represent a distinct marker of upcoming AD independently from memory deficits.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): TVA, visual attention, visual threshold, processing speed, VSTM, visual deficits
    School: Birkbeck Schools and Departments > School of Science > Psychological Sciences
    Depositing User: Administrator
    Date Deposited: 17 Dec 2010 11:52
    Last Modified: 17 Apr 2013 12:19
    URI: http://eprints.bbk.ac.uk/id/eprint/2521

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