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    New rapamycin derivatives by precursor-directed biosynthesis

    Lowden, Philip and Böhm, G.A. and Metcalfe, S. and Staunton, J. and Leadlay, P.F. (2004) New rapamycin derivatives by precursor-directed biosynthesis. ChemBioChem 5 (4), pp. 535-538. ISSN 1439-4227.

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    Abstract

    Possible new immunosuppressants through biosynthesis: Derivatives of the immunosuppressant rapamycin, such as analogue 3, are obtained by feeding simple carboxylic acids to the rapamycin‐producing organism. Incorporation of these alternative starter units appears to be preceded by their specific hydroxylation.

    Metadata

    Item Type: Article
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Depositing User: Sarah Hall
    Date Deposited: 07 May 2019 15:23
    Last Modified: 07 May 2019 15:23
    URI: http://eprints.bbk.ac.uk/id/eprint/27430

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