BIROn - Birkbeck Institutional Research Online

    Minocycline and doxycycline are not beneficial in a model of Huntington's disease

    Smith D.L. and Woodman B. and Mahal A. and Sathasivam K. and Ghazi-Noori S. and Lowden, Philip and Bates G.P. and Hockly E. (2003) Minocycline and doxycycline are not beneficial in a model of Huntington's disease. Annals of Neurology 54 (2), pp. 186-196. ISSN 0364-5134.

    Full text not available from this repository.

    Abstract

    Huntington's Disease (HD) is an inherited neurological disorder causing movement impairment, personality changes, dementia, and premature death, for which there is currently no effective therapy. The modified tetracycline antibiotic, minocycline, has been reported to ameliorate the disease phenotype in the R6/2 mouse model of HD. Because the tetracyclines have also been reported to inhibit aggregation in other amyloid disorders, we have investigated their ability to inhibit huntingtin aggregation and further explored their efficacy in preclinical mouse trials. We show that tetracyclines are potent inhibitors of huntingtin aggregation in a hippocampal slice culture model of HD at an effective concentration of 30μM. However, despite achieving tissue levels approaching this concentration by oral treatment of R6/2 mice with minocycline, we observed no clear difference in their behavioral abnormalities, or in aggregate load postmortem. In the light of these new data, we would advise that caution be exercised in proceeding into human clinical trials of minocycline. Ann Neurol 2003

    Metadata

    Item Type: Article
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Depositing User: Sarah Hall
    Date Deposited: 07 May 2019 15:46
    Last Modified: 07 May 2019 15:46
    URI: http://eprints.bbk.ac.uk/id/eprint/27432

    Statistics

    Downloads
    Activity Overview
    0Downloads
    61Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item