BIROn - Birkbeck Institutional Research Online

    Optimised oligonucleotide substrates to assay XPF ERCC1 nuclease activity for the discovery of DNA repair inhibitors

    Thomas, A.M. and Brolih, S. and McGouran, J. and El-Sagheer, A.H. and Ptchelkine, D. and Jones, M. and McDonald, Neil Q. and McHugh, P.J. and Brown, T. (2019) Optimised oligonucleotide substrates to assay XPF ERCC1 nuclease activity for the discovery of DNA repair inhibitors. Chemical Communications 55 , pp. 11671-11674. ISSN 1359-7345.

    [img]
    Preview
    Text
    28891a.pdf - Published Version of Record
    Available under License Creative Commons Attribution.

    Download (2MB) | Preview

    Abstract

    We report the design and optimisation of novel oligonucleotide substrates for a sensitive fluorescence assay for high-throughput screening and functional studies of the DNA repair enzyme, XPF-ERCC1, with a view to accelerating inhibitor and drug discovery

    Metadata

    Item Type: Article
    School: Birkbeck Faculties and Schools > Faculty of Science > School of Natural Sciences
    Research Centres and Institutes: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Neil Mcdonald
    Date Deposited: 16 Sep 2019 08:06
    Last Modified: 02 Aug 2023 17:54
    URI: https://eprints.bbk.ac.uk/id/eprint/28891

    Statistics

    Activity Overview
    6 month trend
    198Downloads
    6 month trend
    190Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item