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Different approaches to relating genotype to phenotype in developmental disorders

Karmiloff-Smith, Annette and Scerif, G. and Thomas, Michael S.C. (2002) Different approaches to relating genotype to phenotype in developmental disorders. Developmental Psychobiology 40 (3), pp. 311-322. ISSN 0012-1630.

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Discusses the complex problem of relating genotype to phenotype and challenge the simple mapping of genes to higher level cognitive modules. The authors examine various methods that have been used to investigate this relation including quantitative genetics, molecular genetics, animal models, and in-depth psychological and computational studies of developmental disorders. Both single gene and multiple gene disorders indicate that the relationship between genotype and phenotype is very indirect and that, rather than identifying mere snapshots of developmental outcomes, the process of ontogenetic development itself must be taken into account.

Item Type: Article
Additional Information: Under review, full-text locked until further notice
Keyword(s) / Subject(s): Genotype-phenotype relations, developmental disorders, animal models, genetics, ontogenetic development
School or Research Centre: Birkbeck Schools and Research Centres > School of Science > Psychological Sciences
Depositing User: Administrator
Date Deposited: 02 Dec 2010 09:30
Last Modified: 11 Oct 2016 12:00

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