Different approaches to relating genotype to phenotype in developmental disorders
Karmiloff-Smith, Annette and Scerif, G. and Thomas, Michael S.C. (2002) Different approaches to relating genotype to phenotype in developmental disorders. Developmental Psychobiology 40 (3), pp. 311-322. ISSN 0012-1630.
Text (Pre-print (unrefereed))
Restricted to Repository staff only
Discusses the complex problem of relating genotype to phenotype and challenge the simple mapping of genes to higher level cognitive modules. The authors examine various methods that have been used to investigate this relation including quantitative genetics, molecular genetics, animal models, and in-depth psychological and computational studies of developmental disorders. Both single gene and multiple gene disorders indicate that the relationship between genotype and phenotype is very indirect and that, rather than identifying mere snapshots of developmental outcomes, the process of ontogenetic development itself must be taken into account.
|Additional Information:||Under review, full-text locked until further notice|
|Keyword(s) / Subject(s):||Genotype-phenotype relations, developmental disorders, animal models, genetics, ontogenetic development|
|School:||Birkbeck Schools and Departments > School of Science > Psychological Sciences|
|Research Centre:||Educational Neuroscience, Centre for, Birkbeck Knowledge Lab, Brain and Cognitive Development, Centre for (CBCD)|
|Date Deposited:||02 Dec 2010 09:30|
|Last Modified:||09 Dec 2016 11:15|
Additional statistics are available via IRStats2.