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Early nascent chain folding events on the ribosome

Cabrita, L.D. and Dobson, C.M. and Christodoulou, John (2010) Early nascent chain folding events on the ribosome. Israel Journal of Chemistry 50 (1), pp. 99-108. ISSN 0021-2148.

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Official URL: http://dx.doi.org/10.1002/ijch.201000015

Abstract

To maintain optimal protein homeostasis within the cell, a complex interplay exists between factors determining the production, transport, and folding of nascent chains. Here we review the evidence for the structural and dynamical properties of nascent polypeptide chains as they emerge from the ribosome and that enable them to acquire their biologically active, three-dimensional structures. In particular, we focus on the application of NMR spectroscopy, which is now emerging as a powerful technique to probe the behavior and properties of emerging nascent chains.

Item Type: Article
Keyword(s) / Subject(s): protein folding, ribosome, NMR spectroscopy, structural biology, nascent chain, biosynthesis, PEPTIDYL-TRANSFER-RNA, TRIGGER FACTOR, EXIT TUNNEL, TRANSLATING RIBOSOMES, POLYPEPTIDE-CHAIN, NMR-SPECTROSCOPY, IN-VITRO, EF-G, FIREFLY LUCIFERASE, PROTEIN-SYNTHESIS
School or Research Centre: Birkbeck Schools and Research Centres > School of Science > Biological Sciences
Depositing User: Administrator
Date Deposited: 18 Feb 2011 15:47
Last Modified: 17 Apr 2013 12:20
URI: http://eprints.bbk.ac.uk/id/eprint/3088

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