Early nascent chain folding events on the ribosome
Cabrita, L.D. and Dobson, C.M. and Christodoulou, John (2010) Early nascent chain folding events on the ribosome. Israel Journal of Chemistry 50 (1), pp. 99-108. ISSN 0021-2148.
To maintain optimal protein homeostasis within the cell, a complex interplay exists between factors determining the production, transport, and folding of nascent chains. Here we review the evidence for the structural and dynamical properties of nascent polypeptide chains as they emerge from the ribosome and that enable them to acquire their biologically active, three-dimensional structures. In particular, we focus on the application of NMR spectroscopy, which is now emerging as a powerful technique to probe the behavior and properties of emerging nascent chains.
|Keyword(s) / Subject(s):||protein folding, ribosome, NMR spectroscopy, structural biology, nascent chain, biosynthesis, PEPTIDYL-TRANSFER-RNA, TRIGGER FACTOR, EXIT TUNNEL, TRANSLATING RIBOSOMES, POLYPEPTIDE-CHAIN, NMR-SPECTROSCOPY, IN-VITRO, EF-G, FIREFLY LUCIFERASE, PROTEIN-SYNTHESIS|
|School:||Birkbeck Schools and Departments > School of Science > Biological Sciences|
|Research Centre:||Structural Molecular Biology, Institute of (ISMB)|
|Date Deposited:||18 Feb 2011 15:47|
|Last Modified:||06 Dec 2016 10:48|
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