Neural and behavioural indices of face processing in siblings of children with autism spectrum disorder (ASD): a longitudinal study from infancy to mid-childhood

Shephard, E. and Milosavljevic, Bosiljka and Mason, Luke and Elsabbagh, Mayada and Tye, C. and Gliga, Teodora and Jones, Emily J.H. and Charman, T. and Johnson, Mark H. and Baron-Cohen, S. and Bedford, Rachael and Bolton, P. and Chandler, S. and Fernandes, J. and Garwood, H. and Hudry, K. and Pasco, G. and Pickles, A. and Tucker, L. and Volein, A. (2020) Neural and behavioural indices of face processing in siblings of children with autism spectrum disorder (ASD): a longitudinal study from infancy to mid-childhood. Cortex 127 , pp. 162-179. ISSN 0010-9452.

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Official URL: https://doi.org/10.1016/j.cortex.2020.02.008

Abstract

Impaired face processing is proposed to play a key role in the early development of autism spectrum disorder (ASD) and to be an endophenotypic trait which indexes genetic risk for the disorder. However, no published work has examined the development of face processing abilities from infancy into the school-age years and how they relate to ASD symptoms in individuals with or at high-risk for ASD. In this novel study we investigated neural and behavioural measures of face processing at age 7 months and again in mid-childhood (age 7 years) as well as social-communication and sensory symptoms in siblings at high (n = 42) and low (n = 35) familial risk for ASD. In mid-childhood, high-risk siblings showed atypical P1 and N170 event-related potential correlates of face processing and, for high-risk boys only, poorer face and object recognition ability compared to low-risk siblings. These neural and behavioural atypicalities were associated with each other and with higher social-communication and sensory symptoms in mid-childhood. Additionally, more atypical neural correlates of object (but not face) processing in infancy were associated with less right-lateralised (more atypical) N170 amplitudes and greater social-communication problems in mid-childhood. The implications for models of face processing in ASD are discussed.

Metadata

Item Type:	Article
Keyword(s) / Subject(s):	autism spectrum disorder (ASD), infant siblings, face processing, EEG, development
School:	Birkbeck Faculties and Schools > Faculty of Science > School of Psychological Sciences
Research Centres and Institutes:	Brain and Cognitive Development, Centre for (CBCD)
Depositing User:	Emily Jones
Date Deposited:	06 Mar 2020 07:10
Last Modified:	02 Aug 2023 17:57
URI:	https://eprints.bbk.ac.uk/id/eprint/31029

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