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    Sodium channelopathies and pain

    Lampert, A. and O’Reilly, Andrias O. and Reeh, P. and Leffler, A. (2010) Sodium channelopathies and pain. Pflügers Archiv - European Journal of Physiology 460 (2), pp. 249-263. ISSN 0031-6768.

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    Abstract

    Chronic pain often represents a severe, debilitating condition. Up to 10% of the worldwide population are affected, and many patients are poorly responsive to current treatment strategies. Nociceptors detect noxious conditions to produce the sensation of pain, and this signal is conveyed to the CNS by means of action potentials. The fast upstroke of action potentials is mediated by voltage-gated sodium channels, of which nine pore-forming α-subunits (Nav1.1–1.9) have been identified. Heterogeneous functional properties and distinct expression patterns denote specialized functions of each subunit. The Nav1.7 and Nav1.8 subunits have emerged as key molecules involved in peripheral pain processing and in the development of an increased pain sensitivity associated with inflammation and tissue injury. Several mutations in the SCN9A gene encoding for Nav1.7 have been identified as important cellular substrates for different heritable pain syndromes. This review aims to cover recent progress on our understanding of how biophysical properties of mutant Nav1.7 translate into an aberrant electrogenesis of nociceptors. We also recapitulate the role of Nav1.8 for peripheral pain processing and of additional sodium channelopathies which have been linked to disorders with pain as a significant component.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Sodium channel, mutation, Nav1.7, pain, patch-clamp, three dimensional computer modeling
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Depositing User: Administrator
    Date Deposited: 31 Mar 2011 11:11
    Last Modified: 17 Apr 2013 12:20
    URI: http://eprints.bbk.ac.uk/id/eprint/3229

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