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The effects of linear and cyclic analogs of Locmi-DH, Dippu-DH46 and Dippu-DH31 on appetitive behavior in Locusta migratoria

Kaskani, C. and Poulos, C.P. and Goldsworthy, Graham J. (2012) The effects of linear and cyclic analogs of Locmi-DH, Dippu-DH46 and Dippu-DH31 on appetitive behavior in Locusta migratoria. Peptides 34 (1), pp. 258-261. ISSN 0196-9781.

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Official URL: http://dx.doi.org/10.1016/j.peptides.2011.04.009

Abstract

The effects of analogs of the diuretic peptides Locmi-DH, Dippu-DH46 and Dippu-DH31 on two aspects of appetitive behavior are investigated in previously food-deprived nymphs of Locusta migratoria. The analogs tested are the C-terminal 15-mer and nonapeptides and their corresponding cyclic analogs. At a nominal dose of 1 pmol injected per nymph, the linear fragments and their cyclic analogs of Dippu-DH46 display no significant effects on the latency to feed or on the length of the first meal in nymphs. However, at the same dose, the linear fragments of Dippu-DH31 and their cyclic analogs, and analogs of Locmi-DH modulate appetitive behavior: they are anorexigenic in reducing the duration of the first meal, and generally increasing the latency to feed. The cyclic analogs of Dippu-DH31 are at least as effective as their linear counterparts in influencing these aspects of appetitive behavior in locust nymphs.

Item Type: Article
School or Research Centre: Birkbeck Schools and Research Centres > School of Science > Biological Sciences
Depositing User: Administrator
Date Deposited: 04 May 2011 08:30
Last Modified: 17 Apr 2013 12:20
URI: http://eprints.bbk.ac.uk/id/eprint/3268

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