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Architecture of the Helicobacter pylori Cag-type IV secretion system

Terradot, L. and Waksman, Gabriel (2011) Architecture of the Helicobacter pylori Cag-type IV secretion system. FEBS Journal 278 (8), pp. 1213-22. ISSN 1742-464X.

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Official URL: http://dx.doi.org/10.1111/j.1742-4658.2011.08037.x

Abstract

Type IV secretion systems (T4SS) are macromolecular assemblies used by bacteria to transport material across their membranes. T4SS are generally composed of a set of twelve proteins (VirB1-11 and VirD4). This represents a dynamic machine powered by three ATPases. T4SS are widespread in pathogenic bacteria where they are often used to deliver effectors into host cells. For example, the human pathogen Helicobacter pylori encodes a T4SS, the Cag-T4SS, which mediates the injection of the toxin CagA. We review the progress made in the past decade in our understanding of T4SS architecture. We translate this new knowledge to derive an understanding of the structure of the H. pylori Cag system, and use recent protein-protein interaction data to refine this model.

Item Type: Article
Keyword(s) / Subject(s): bacterial pathogenesis, CagA, secretion system, stomach cancer, translocation
School or Research Centre: Birkbeck Schools and Research Centres > School of Science > Biological Sciences
Depositing User: Administrator
Date Deposited: 20 May 2011 08:47
Last Modified: 17 Apr 2013 12:20
URI: http://eprints.bbk.ac.uk/id/eprint/3357

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