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Mycobacterium tuberculosis: immune evasion, latency and reactivation

Gupta, Antima and Kaul, Akshay and Tsolaki, A.G. and Kishore, U. and Bhakta, Sanjib (2012) Mycobacterium tuberculosis: immune evasion, latency and reactivation. Immunobiology 217 (3), pp. 363-374. ISSN 0171-2985.

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Official URL: http://dx.doi.org/10.1016/j.imbio.2011.07.008

Abstract

One-third of the global human population harbours Mycobacterium tuberculosis in dormant form. This dormant or latent infection presents a major challenge for global efforts to eradicate tuberculosis, because it is a vast reservoir of potential reactivation and transmission. This article explains how the pathogen evades the host immune response to establish a latent infection, and how it emerges from a state of latency to cause reactivation disease. This review highlights the key factors responsible for immune evasion and reactivation. It concludes by identifying interesting candidates for drug or vaccine development, as well as identifying unresolved questions for the future research.

Item Type: Article
Keyword(s) / Subject(s): Immune evasion, immune response, latency, Mycobacterium tuberculosis, reactivation
School or Research Centre: Birkbeck Schools and Research Centres > School of Science > Biological Sciences
Depositing User: Administrator
Date Deposited: 19 Jul 2011 08:03
Last Modified: 17 Apr 2013 12:21
URI: http://eprints.bbk.ac.uk/id/eprint/3810

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