BIROn - Birkbeck Institutional Research Online

    Structural and thermodynamic analysis of the hetero-association of theophylline with aromatic drug molecules

    Andrejuk, D.D. and Hernandez Santiago, A.A. and Khomich, V.V. and Voronov, V.K. and Davies, David B. and Evstigneev, M.P. (2008) Structural and thermodynamic analysis of the hetero-association of theophylline with aromatic drug molecules. Journal of Molecular Structure 889 (1-3), pp. 229-236. ISSN 0022-2860.

    Full text not available from this repository.

    Abstract

    The hetero-association of theophylline (THP) with other biologically-active aromatic molecules (e.g. the anti-cancer drugs daunomycin and novantrone, the antibiotic norfloxacin, the vitamin flavin-mononucleotide and two mutagens ethidium bromide and proflavine) has been studied by NMR in aqueous-salt solution (0.1 M Na-phosphate buffer, pD 7.1). It was found that THP shows an essentially similar hetero-association ability as caffeine (CAF) towards aromatic drugs, except for novantrone (NOV), which has much less affinity to THP than CAF as a result of energetically unfavourable orthogonal orientation of the chromophores of THP and NOV in the hetero-complex.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): Hetero-association, Theophylline, aromatic drugs, NMR, interceptor
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Depositing User: Administrator
    Date Deposited: 29 Jul 2011 08:48
    Last Modified: 17 Apr 2013 12:21
    URI: http://eprints.bbk.ac.uk/id/eprint/3916

    Statistics

    Downloads
    Activity Overview
    0Downloads
    292Hits

    Additional statistics are available via IRStats2.

    Archive Staff Only (login required)

    Edit/View Item Edit/View Item