Nachman, R.J. and Fehrentz, J.A. and Martinez, J. and Kaczmarek, K. and Zabrocki, J. and Coast, Geoffrey M. (2007) A C-terminal aldehyde analog of the insect kinins inhibits diuresis in the housefly. Peptides 28 (1), 146 - 152. ISSN 0196-9781.Full text not available from this repository.
The insect kinins are present in a wide variety of insects and function as potent diuretic peptides in flies. A C-terminal aldehyde insect kinin analog, Fmoc-RFFPWG-H (R-LK-CHO), demonstrates stimulation of Malpighian tubule fluid secretion in crickets, but shows inhibition of both in vitro and in vivo diuresis in the housefly. R-LK-CHO reduced the total amount of urine voided over 3 h from flies injected with 1 μL of distilled water by almost 50%. The analog not only inhibits stimulation of housefly fluid secretion by the native kinin Musdo-K, but also by thapsigargin, a SERCA inhibitor, and by ionomycin, a calcium ionophore. The activity of R-LK-CHO is selective, however, as related C-terminal aldehyde analogs do not demonstrate an inhibitory response on housefly fluid secretion. The selective inhibitory activity of R-LK-CHO on housefly tubules represents an important lead in the development of environmentally friendly insect management agents based on the insect kinins.
|Keyword(s) / Subject(s):||Insect kinins, pest control, musca domestica|
|School or Research Centre:||Birkbeck Schools and Research Centres > School of Science > Biological Sciences|
|Date Deposited:||02 Aug 2011 10:18|
|Last Modified:||17 Apr 2013 12:21|
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