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A C-terminal aldehyde analog of the insect kinins inhibits diuresis in the housefly

Nachman, R.J. and Fehrentz, J.A. and Martinez, J. and Kaczmarek, K. and Zabrocki, J. and Coast, Geoffrey M. (2007) A C-terminal aldehyde analog of the insect kinins inhibits diuresis in the housefly. Peptides 28 (1), 146 - 152. ISSN 0196-9781.

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The insect kinins are present in a wide variety of insects and function as potent diuretic peptides in flies. A C-terminal aldehyde insect kinin analog, Fmoc-RFFPWG-H (R-LK-CHO), demonstrates stimulation of Malpighian tubule fluid secretion in crickets, but shows inhibition of both in vitro and in vivo diuresis in the housefly. R-LK-CHO reduced the total amount of urine voided over 3 h from flies injected with 1 μL of distilled water by almost 50%. The analog not only inhibits stimulation of housefly fluid secretion by the native kinin Musdo-K, but also by thapsigargin, a SERCA inhibitor, and by ionomycin, a calcium ionophore. The activity of R-LK-CHO is selective, however, as related C-terminal aldehyde analogs do not demonstrate an inhibitory response on housefly fluid secretion. The selective inhibitory activity of R-LK-CHO on housefly tubules represents an important lead in the development of environmentally friendly insect management agents based on the insect kinins.

Item Type: Article
Keyword(s) / Subject(s): Insect kinins, pest control, musca domestica
School or Research Centre: Birkbeck Schools and Research Centres > School of Science > Biological Sciences
Depositing User: Administrator
Date Deposited: 02 Aug 2011 10:18
Last Modified: 17 Apr 2013 12:21

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