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    On the origin of the decrease in stability of the DNA hairpin d(GCGAAGC) on complexation with aromatic drugs

    Kostjukov, V.V. and Lantushenko, A.O. and Davies, David B. and Evstigneev, M.P. (2007) On the origin of the decrease in stability of the DNA hairpin d(GCGAAGC) on complexation with aromatic drugs. Biophysical Chemistry 129 (1), 56 - 59. ISSN 0301-4622.

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    Abstract

    Molecular dynamics simulations of drug–DNA complexes have been carried out in order to explain the experimentally observed decrease in thermal stability of the DNA hairpin d(GCGAAGC) on binding the aromatic drug molecules, daunomycin, ethidium bromide, novantrone and proflavine. This complexation behavior is in contrast to the stabilizing effect of the same aromatic drug molecules on DNA duplexes. Analysis of the energy parameters and the hydration properties of the complexes shows that the main factor correlating with the decrease in melting temperatures of the drug–hairpin complexes is the number of water bridges, with a reduction of at least 40% on ligand binding.

    Metadata

    Item Type: Article
    Keyword(s) / Subject(s): d(GCGAAGC), aromatic ligand, water bridges, thermal stability, molecular dynamics
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Depositing User: Administrator
    Date Deposited: 02 Aug 2011 10:10
    Last Modified: 17 Apr 2013 12:21
    URI: http://eprints.bbk.ac.uk/id/eprint/4006

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