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Bromopyridazinedione-mediated protein and peptide bioconjugation

Chudasama, V. and Smith, M.E.B. and Schumacher, F.F. and Papaioannou, D. and Waksman, Gabriel and Baker, J.R. and Caddick, S. (2011) Bromopyridazinedione-mediated protein and peptide bioconjugation. Chemical Communications 47 (31), pp. 8781-8783. ISSN 1359-7345.

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Bromopyridazinedione-mediated bioconjugation to a cysteine containing protein and a disulfide containing peptide is described. The conjugates are cleavable in an excess of thiol, including cytoplasmically-relevant concentrations of glutathione, and show a high level of hydrolytic stability. The constructs have the potential for four points of chemical attachment.

Item Type: Article
School or Research Centre: Birkbeck Schools and Research Centres > School of Science > Biological Sciences
Depositing User: Administrator
Date Deposited: 12 Aug 2011 11:17
Last Modified: 17 Apr 2013 12:21

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