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    Kaposi's Sarcoma-Associated Herpesvirus vFLIP and Human T Cell Lymphotropic Virus Type 1 Tax Oncogenic Proteins Activate I B Kinase Subunit   by Different Mechanisms Independent of the Physiological Cytokine-Induced Pathways

    Shimizu, A. and Baratchian, M. and Takeuchi, Y. and Escors, D. and MacDonald, D. and Barrett, Tracey E. and Bagneris, Claire and Collins, M. and Noursadeghi, M. (2011) Kaposi's Sarcoma-Associated Herpesvirus vFLIP and Human T Cell Lymphotropic Virus Type 1 Tax Oncogenic Proteins Activate I B Kinase Subunit   by Different Mechanisms Independent of the Physiological Cytokine-Induced Pathways. Journal of Virology 85 (14), pp. 7444-7448. ISSN 0022-538X.

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    Abstract

    Activation of I{kappa}B kinase subunit {gamma} (IKK{gamma}), a key regulator of the classical NF-{kappa}B pathway, by the vFLIP protein of Kaposi's sarcoma-associated herpesvirus (KSHV) and the Tax protein of human T cell lymphotropic virus type 1 (HTLV1) is essential for virus-associated cancer. We show that vFLIP and Tax activate this pathway by different interactions with IKK{gamma} and independently of the ubiquitin-mediated signaling pathways induced by cytokines. Our data provide new insights into the mechanisms by which IKK{gamma} can be activated and show that NF-{kappa}B activation by oncogenic viruses can be targeted without affecting physiologically important pathways.

    Metadata

    Item Type: Article
    School: Birkbeck Schools and Departments > School of Science > Biological Sciences
    Research Centre: Structural Molecular Biology, Institute of (ISMB)
    Depositing User: Administrator
    Date Deposited: 15 Aug 2011 15:24
    Last Modified: 06 Dec 2016 10:41
    URI: http://eprints.bbk.ac.uk/id/eprint/4088

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