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NaChBac: the long lost sodium channel ancestor

Charalambous, Kalypso and Wallace, Bonnie A. (2011) NaChBac: the long lost sodium channel ancestor. Biochemistry 50 (32), pp. 6742-6752. ISSN 0006-2960.

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Official URL: http://dx.doi.org/10.1021/bi200942y

Abstract

In excitable cells, the main mediators of sodium conductance across membranes are voltage-gated sodium channels (Na(V)s). Eukaryotic Na(V)s are essential elements in neuronal signaling and muscular contraction and in humans have been causally related to a variety of neurological and cardiovascular channelopathies. They are complex heavily glycosylated intrinsic membrane proteins present in only trace quantities that have proven to be challenging objects of study. However, in recent years, a number of simpler prokaryotic sodium channels have been identified, with NaChBac from Bacillus halodurans being the most well-characterized to date. The availability of a bacterial Na(V) that is amenable to heterologous expression and functional characterization in both bacterial and mammalian systems has provided new opportunities for structure--function studies. This review describes features of NaChBac as an exemplar of this class of bacterial channels, compares prokaryotic and eukaryotic Na(V)s with respect to their structural organization, pharmacological profiling, and functional kinetics, and discusses how voltage-gated ion channels may have evolved to deal with the complex functional demands of higher organisms.

Item Type: Article
Keyword(s) / Subject(s): Amino Acid Sequence, Bacillus, Glycosylation, Humans, Kinetics, Molecular Sequence Data, Protein Conformation, Sequence Homology, Amino Acid, Sodium Channels, Structure-Activity Relationship
School or Research Centre: Birkbeck Schools and Research Centres > School of Science > Biological Sciences
Depositing User: Administrator
Date Deposited: 16 Nov 2011 09:26
Last Modified: 17 Apr 2013 12:21
URI: http://eprints.bbk.ac.uk/id/eprint/4287

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