Pilus biogenesis at the outer membrane of Gram-negative bacterial pathogens
Allen, William J. and Phan, Gilles and Waksman, Gabriel (2012) Pilus biogenesis at the outer membrane of Gram-negative bacterial pathogens. Current Opinion in Structural Biology 22 (4), pp. 500-506. ISSN 0959-440X.
Pili belong to a broad class of bacterial surface structures that play a key role in infection and pathogenicity. The largest and best characterised pilus biogenesis system — the chaperone–usher pathway — is particularly remarkable in its ability to synthesise and display highly organised structures at the outer membrane without any input from endogenous energy sources. The past few years have heralded exciting new developments in our understanding of the structural biology and mechanism of pilus assembly, which are discussed in this review. Such knowledge will be particularly important in the future, as we approach an era of widespread resistance to common antibiotics and require new targets.
|School:||Birkbeck Schools and Departments > School of Science > Biological Sciences|
|Research Centre:||Structural Molecular Biology, Institute of (ISMB)|
|Depositing User:||Users 774 not found.|
|Date Deposited:||07 Mar 2012 14:28|
|Last Modified:||06 Dec 2016 10:46|
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