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Pilus biogenesis at the outer membrane of Gram-negative bacterial pathogens

Allen, William J. and Phan, Gilles and Waksman, Gabriel (2012) Pilus biogenesis at the outer membrane of Gram-negative bacterial pathogens. Current Opinion in Structural Biology 22 (4), pp. 500-506. ISSN 0959-440X.

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Official URL: http://dx.doi.org/10.1016/j.sbi.2012.02.001

Abstract

Pili belong to a broad class of bacterial surface structures that play a key role in infection and pathogenicity. The largest and best characterised pilus biogenesis system — the chaperone–usher pathway — is particularly remarkable in its ability to synthesise and display highly organised structures at the outer membrane without any input from endogenous energy sources. The past few years have heralded exciting new developments in our understanding of the structural biology and mechanism of pilus assembly, which are discussed in this review. Such knowledge will be particularly important in the future, as we approach an era of widespread resistance to common antibiotics and require new targets.

Item Type: Article
School or Research Centre: Birkbeck Schools and Research Centres > School of Science > Biological Sciences
Depositing User: Mr Paul Rigg
Date Deposited: 07 Mar 2012 14:28
Last Modified: 17 Apr 2013 12:22
URI: http://eprints.bbk.ac.uk/id/eprint/4621

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