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Identification of congenital muscular dystonia 2 associated with an inherited GlyT2 defect in Belgian Blue cattle from the United Kingdom

Gill, J.L. and James, Victoria M. and Carta, E. and Harris, D. and Topf, Maya and Scholes, S.F.E. and Hateley, G. and Harvey, R.J. (2012) Identification of congenital muscular dystonia 2 associated with an inherited GlyT2 defect in Belgian Blue cattle from the United Kingdom. Animal Genetics 43 (3), pp. 267-270. ISSN 0268-9146.

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Official URL: http://dx.doi.org/10.1111/j.1365-2052.2011.02255.x

Abstract

Two newborn Belgian Blue calves from a farm in the United Kingdom exhibited lateral recumbency, low head carriage and transient muscle spasms following tactile or auditory stimulation. DNA sequence analysis indicated that both calves were homozygous for the recessive congenital muscular dystonia type 2 (CMD2) mutation (c.809T>C, p.Leu270Pro) in SLC6A5, encoding the neuronal glycine transporter GlyT2. Further testing of animals from the index farm and a sample of Belgian Blue sires revealed an unexpectedly high frequency of CMD2 carriers. This implies that linked quantitative trait loci may be influencing the prevalence of CMD2 in the estimated 55 000 Belgian Blue cattle in the United Kingdom. We have therefore developed new inexpensive tests for the CMD2 allele that can be used to confirm diagnosis, identify carriers and guide future breeding strategy, thus avoiding animal distress/premature death and minimizing the future economic impact of this disorder.

Item Type: Article
Keyword(s) / Subject(s): Belgian Blue, CMD2, congenital muscular dystonia type 2, glycine transporter, GlyT2
School or Research Centre: Birkbeck Schools and Research Centres > School of Science > Biological Sciences
Depositing User: Administrator
Date Deposited: 24 Apr 2012 11:44
Last Modified: 13 Jun 2013 09:28
URI: http://eprints.bbk.ac.uk/id/eprint/4725

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