Ronald, Angelica and Butcher, L.M. and Docherty, S.J. and Davis, O.S.P. and Schalkwyk, L.C. and Craig, I.W. and Plomin, R. (2010) A genome-wide association study of social and non-social autistic-like traits in the general population using pooled DNA, 500 K SNP microarrays and both community and diagnosed autism replication samples. Behavior Genetics 40 (1), pp. 31-45. ISSN 0001-8244.Full text not available from this repository.
Two separate genome-wide association studies were conducted to identify single nucleotide polymorphisms (SNPs) associated with social and nonsocial autistic-like traits. We predicted that we would find SNPs associated with social and non-social autistic-like traits and that different SNPs would be associated with social and nonsocial. In Stage 1, each study screened for allele frequency differences in ~430,000 autosomal SNPs using pooled DNA on microarrays in high-scoring versus low-scoring boys from a general population sample (N = ~400/group). In Stage 2, 22 and 20 SNPs in the social and non-social studies, respectively, were tested for QTL association by individually genotyping an independent community sample of 1,400 boys. One SNP (rs11894053) was nominally associated (P < .05, uncorrected for multiple testing) with social autistic-like traits. When the sample was increased by adding females, 2 additional SNPs were nominally significant (P < .05). These 3 SNPs, however, showed no significant association in transmission disequilibrium analyses of diagnosed ASD families.
|Keyword(s) / Subject(s):||autistic traits, genome-wide association, autism, microarrays, heritability, pooling|
|School or Research Centre:||Birkbeck Schools and Research Centres > School of Science > Psychology|
|Depositing User:||Sarah Hall|
|Date Deposited:||22 Jun 2012 07:10|
|Last Modified:||17 Apr 2013 12:23|
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